According to the DVD commentary, a rejected plotline had Roger going to the family he was with before the Smiths, who would have been played by E.T. actors Henry Thomas and Drew Barrymore.
The montage of Stan and Francine's life with Mr. PiBB is accompanied by Kim Mitchell's 1985 song, "Go For Soda".
The song played during the montage of Stan and Francine's hunt for signatures is G. Love & Special Sauce "Cold Beverage".
The flashback during Roger's song shows how Stan was able to get Roger to come live with them four years ago by introducing him as a present at Steve's tenth birthday. Contrary to Steve's reaction, Hayley and Francine are horrified at the first sight of him.
In the "When I Was His Alien" musical montage, the girl who slaps Steve when he tries to get his arms around her is Kim from "Stan Knows Best".
The car confused for the Mr. PiBB Mobile is a Volkswagon Jetta.
When Roger is crossing a busy motorway he is clearly seen drinking a bottle of Joe Daniello's Whiskey, a spoof version of Jack Daniel's and a play on the director. In the same scene, Stan Smith can also be seen driving behind Roger wearing his suit and driving his SUV.
During the flashback montage, a parody of the Patrick Nagel painting "Sunglasses" can be seen on the wall.