Stan cries when discussing David Hasselhoff, referring to an internet meme of him crying while trying to eat a cheeseburger while intoxicated.
Stan's crack dream is a reference to 'male enhancement' products such as Levitra and Cyalis.
During a Biology class, Steve animates a partly dissected frog whilst singing "Hello! Ma Baby", a reference to the Looney Toons cartoon, One Froggy Evening. Steve then animates the frog while singing a parody of "Drop It Like It's Hot", by Snoop Doggy Dog, dubbing the frog, "Snoop Froggy Frog".