The title is a reference to the popular role-playing game, Dungeons and Dragons.
Steve and his friends and later, Jeff and Hayley are playing an MMORPG in the vein of Everquest or World of Warcraft.
Hayley kills the monster in the same manner that Chief Brody killed the shark in Jaws. Except for the final word, she also uses the same line he did before she fires into its mouth: "Smile, you son of a bitch"
Steve's in-game character can be defeated by saying his name backwards, similar to the Superman character Mr. Mxyzptlk. The notable difference being that Agathor dies instantly whenever anybody says his name backwards, while Mxyzptlk must actually be tricked into saying it himself.
Stan finds Francine watching 2 Fast 2 Furious and concludes that she already saw the first film, as it's the only way for her to "understand the highly cerebral storyline".
Roger references the ending of Batman Begins.
The montage with Stan winning race after race and Francine posing on his car are based on the video for Whitesnake's single "Here I Go Again", in which Tawny Kitaen poses in the same manner. The song also plays during this sequence.
Jeff's game character is called Zamfir, a probable reference to noted panpipe virtuoso Gheorghe Zamfir.