One of the channels Roger mentions that Stan is hooked up to is TBS. The following season, American Dad! moved to TBS from FOX.
Frequent background character Earl picks Steve up from his eye doctor appointment in a van with a license plate marked "CHLDLVR".
Ma Ma Ling is fully aware of Jeff's disappearance into space, believing him to be dead.
Klaus questions Stan about seeing Dallas Cowboys fans at the Washington Redskins games when the Cowboys always play in Dallas on Thanksgiving day, saying that people will ask at Comic-Con, referring to the plot holes customarily pointed out by fans at the American Dad! panel at San Diego Comic-Con.