This is the last standard-definition episode of the show.
Stan previously told a family that agreed with keeping the religious aspects out of the public celebration of Christmas that he couldn't wait for the Rapture in "The Best Christmas Story Never".
When Roger is dressed as Moses, the six commandments on his tablets are "Surf," "Dooble," "Chow," "Party," "Helmet," and "Sleep".
Stan mentions actor John Goodman.
At the arena where the fake Jesus is to appear, the 1980s rock group of Hall & Oates was to appear, however, John Oates had apparently been Raptured, leaving Darryl Hall behind. In a notable twist, Darryl Hall had just previously appeared as an angel and John Oates as a devil in "A Brown Thanksgiving" episode of The Cleveland Show.
When Jesus rides his motorcycle into New Denver, he passes a hanging skeleton wearing a football uniform bearing #7 which was John Elway's number for the Denver Broncos.
When Roger is looking for his spaceship parts, he holds up a sweatshirt that says "Hard Rock Cafe Tucson". However, there isn't a Hard Rock Cafe in Tucson, AZ.
This is one of the few episodes where Klaus has no lines as he's seen only as mantlepiece.
When Stan and Jesus enter The Anti-Christ's hall, a parody of the movie The Omen's theme "Ave Satani" starts to play.
Michelle the Lawyer returns in this episode with a new job as an escort to people's personal Heaven.
In the bar when Jesus comes to recruit Stan, the song "Barael's Blade" by The Sword is playing in the background.