Sheila is Dick Reynolds' ex-wife.
In "Threat Levels", Sheila got a job in which she earned more money than Dick did. Dick did not initially mind, but she kept earning more and more, and eventually his genitals disappeared.
In "Stan's Night Out", Dick catches Sheila having sex with his barber Al. When Dick decides to return to his house and steal back his dog Biscuit that Sheila got in their divorce, he finds Sheila having sex with Al. Dick and Al fight. Al is knocked out and thrown into the trunk of Dick's car which already has two people previously kidnapped during the evening.
Sheila is voiced by D.D. Howard.