• The title is a play on the phrase "Man's best friend".
  • Stan says he's going Lorenzo's oil in seeking his own cure for Kisses, referring to the film of the same name about the true story of two parents search for a cure for their son Lorenzo's adrenoleukodystrophy (ALD).
  • Roger trying to trick Stan with popcorn on his crotch imitates a scene from the film Diner.[1]

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