This episode has a mock celebration of American Dad's 1000th "Vagina Joke" after Roger jokes about the look of a pomegranate. Roger gives a short speech to commemorate the moment during the celebration of most of the series characters behind the scenes.
This episode's B-story is literally about bees.
Roger has a persona he calls "Roger Smith, pretend psychiatrist". He would later adopt the persona of "Dr. Penguin" in "Dr. Klaustus" for such duties.
Also in background of the basement was the Statue of Liberty wood burning from "A Smith In The Hand".
Craig's relocation to Laos is a nod to the history of CIA activities in Laos.
While in therapy, Roger refers to Stan as Mr. Soprano of The Sopranos. Roger quotes Jennifer Melfi from The Sopranos.
Stan and Steve identify Steve's hair color as ginger. Hayley would later be grossed out when Steve gets a red pubic hair in "1600 Candles".
Steve sings part of "It's So Hard to Say Goodbye to Yesterday" by Motown in a black suit before cremating the queen bee on a burning paper boat on the swimming pool and pours honey on the floor after doing so.
Roger's phone number is claimed to be "KLondike 5-2487", indicating the phone number is fictional. The modern equivalent would be 555-2487.